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Shc(Phospho Tyr349) Polyclonal Antibody, 100ul Pathway and Network Analysis Aberrant splice variants expressed in

SKU: 64281704643

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SEK141.00 SEK181.00

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Shc(Phospho Tyr349) Polyclonal Antibody, 100ul Pathway and Network Analysis Aberrant splice variants expressed inThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation.

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Description

Aberrant splice variants expressed in tumor cell lines have also been described

This gene encodes a protein that is secreted by white adipocytes

MFN2 encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network

Members of this protein family have six EF-hand domains which bind calcium

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Shc(Phospho Tyr349) Polyclonal Antibody, 100ul Pathway and Network Analysis Aberrant splice variants expressed inThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation.

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